Chemical Reaction Optimization Algorithm Chemical Reaction Optimization algorithm is a population-based metaheuristic algorithm. Chemical Reaction Optimization algorithm is inspired by Chemical reactions. Chemical Reaction Optimization algorithm is developed by Albert Y.S. Lam and Victor O.K. Li. In this algorithm, Molecular structure (sum all characteristics) is used to compute the solution. Chemical Reaction Optimization algorithm is used to solve optimization problems. Chemistry Basic Fundamentals: Atom / Molecule / Chemical Bonding / Molecular Structure / Molecule Energy / Chemical Reations/ Elementary Reactions Atom: According to Dalton (in 1808), an atom is the smallest part of an element that exists as the smallest entity. 3 important fundamental particles of an atom are Proton, Electron, and Neutron. For Example Oxygen (O), Nitrogen (N), Hydrogen (H), etc. Molecule: A molecule is composed of 2 or more atoms held together by chemical bonds. The molecule is always formed whe